Hello,
CY7C65215 can only be configured in vendor mode for I2C and SPI whereas CY7C65215A part can be configured as Virtual COM port or vendor mode for SPI and I2C.
You can use the CY7C65215A part for I2C and SPI to come up as virtual com port on the host side.
Please refer to the USB-serial SDK for the "Cypress USB-Serial VCP I2CSPI API Guide" and "CyUSBSerialVCP" library which is wrapper on the CDC class.
Best Regards
Yatheesh
