Hi.
Try this.
I don't normally show the UART pins. You can delete the GPIO's on schematic, change UART Pins config tab to no show. From cydwr window, pins tab, you'll see the outline of the 4125 and a list of pin signals (at the right) for assigning to pins. You can dlick on a pin name, RX, and once it's high-lighted, drag it to the pin with a SCB RX name. Do the same for the TX pin.
Doing the TX/RX pin assignments using this method, Creator takes care of sorting out the GPIO pad configuration. That's the way I've always done it.
